Antilipidemic Effect Of Water (H20) Extract Of Desmodium Velutinum Leaves On Albinno Wistar Rats
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This study evaluated the antilipidemic activity of water extracts from leaves
of Desmodium velutinum on albino wistar rats. The phytochemical analysis
of the leaf extract showed the presence of tannins, saponins, alkaloids,
soluble carbohydrates, flavonoids, reducing sugar, steroids, cyanide and
terpenoids. The animals were treated with known drugs (atorvastatin 2ml).
There were significantly reductions in HDL 13.00 1.41 mg/dl LDL 1.20
0.14 mg/dl and triglyceride 39.00 0.14 mg/dl, compared with water extract
of Desmodium velutinum (0.5ml). when administered was found to
significantly reduce lipid plasma which was LDL 1.90 0.00mg/dl,
triglyceride 50.00 0.00mg/dl and increase HDL 25.00 0.00 mg/dl which
is the good cholesterol. The water extract of Desmodium velutinum leaf can
possibly normalize the plasma lipid when compared with the group given
atorvastatin. The phytochemicals analysis showed that the association
between these complexes and compounds and other constituent play an
important role in the biological activity of the leaf. This study suggested that
the water extract of D.velutinum leaf posses hypolipidemic as well as
antilipidemic effect
Title Page
Certification
Dedication
Acknowledgment
List of Tables and Figures
Table of Contents
Abstract
CHAPTER ONE
1.0 Introduction
1.2 Background of the Study
CHAPTER TWO
2.0 Literature Review
2.1 Desmodium velutinum
2.1.2 Biological and Medicinal
2.1.3 Uses of other species Desmodium velutinum
2.2 Plants for Antilipidemic
2.2.1 Advantage of Medicinal Plants for Antilipidemic/
Cardiovascular Diseases over Synthetic Drugs
2.3.1 Classification of Lipoprotein
2.3.2 Function of lipoprotein
2.4 Lipoprotein Disorder
2.5 Antilipidemic Drug (Atorvastatin)
2.5.1 Other Antilipidemic Drugs –
2.5.2 Other therapies
2.5.3 Health Side Effects of Atorvastatin
CHAPTER THREE
Materials and Methods
3.1 Materials
3.1.1 Chemicals and Reagents
3.2 Plant Material -Collection and Identification
3.3 Extraction
3.4 Phytochemical Analysis
3.5 Experimental Animal Model
3.6 Collection of Blood Samples
3.7 Lipid Profile Analysis
CHAPTER FOUR
RESULT
4.0 Statically Analysis
4.1 Phytochemical Results
CHAPTER FIVE
DISCUSSION AND CONCLUSION
5.1 Discussion
5.2 Conclusion
References
INTRODUCTION
1.1 BACKGROUND OF STUDY
Lipid and lipoprotein abnormalities play a major role in the
development and progression of coronary artery diseases. Low levels of high
density lipoprotein cholesterols have been identified as independent
coronary risk factors (Rodrigue et al., 2010). High level of blood cholesterol
is responsible for circulatory system disorder. Increase level of low density
lipoprotein (LDL) is alarming for cardiovascular diseases and their risk is
increased many times (Harman et al., 2011).
In developing countries, the occurrence of heart diseases increases
rapidly (Nordestgard et al., 2010). Medical studies show that about 70% of
adults over 50 years old suffer atherosclerosis. (Sherien and Azza, 2009). A
large number of synthetic hypolipidemic drugs are available in market. Long
term use of these drugs cause serious side effects, and are costly.
A medicinal plant is any plant which in one or more of its organ,
contains substance that can be used for therapeutic purpose or which is a
precursor for synthesis of useful drugs (Sivakumar et al., 2007). Plant
contains a large number of bioactive phytochemicals that are responsible for
pharmacological action of plants and used for development of drugs. Many
medicinal plants have shown their antilipidemic effect and proved their
efficacy in cardiovascular diseases (Nordestgard et al., 2010; Wang, 1999).
One of such plants used very often in the management of the disease
by the traditional medicine practitioners of Eastern Nigeria is Desmodium
velutium, a perennial plant erect or semi-erect shrub or sub-shrub up to 3m
light. It is widely distributed in subtropical Asia and tropical Africa. (Amowi
and Azode, 2012).
Extracts of Desmodium velutium are used traditionally in some
disease conditions particularly aphrodisiac and headache. Hence,
Desomdium velutium may be a source of a pharmacological active agent
useful in the treatment of aches, pains and diarrhoea. In Ghana, native
doctors mix the root of Desmodium lasincarpum with some hot peppers and
use it as enema to cure blood in urine. In Eastern States of Nigeria, the plant
locally known as “Ikeagwuani”. (Onyegbule et al., 2012). In these present
studies, I investigated the antilipidemic activity of the water (H2O) extract of
Desmodium velutinum Leaves on albino wistar rats
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